Search results for " radiation tolerance"

showing 3 items of 3 documents

Cytokine profile of breast cell lines after different radiation doses

2017

Purpose: Ionizing radiation (IR) treatment activates inflammatory processes causing the release of a great amount of molecules able to affect the cell survival. The aim of this study was to analyze the cytokine signature of conditioned medium produced by non-tumorigenic mammary epithelial cell line MCF10A, as well as MCF7 and MDA-MB-231 breast cancer cell lines, after single high doses of IR in order to understand their role in high radiation response. Materials and methods: We performed a cytokine profile of irradiated conditioned media of MCF10A, MCF7 and MDA-MB-231 cell lines treated with 9 or 23 Gy, by Luminex and ELISA analyses. Results: Overall, our results show that both 9 Gy and 23 …

0301 basic medicineIonizing radiationRadiology Nuclear Medicine and ImagingCell SurvivalCytokine profileBreast NeoplasmsInflammationRadiationRadiation ToleranceIonizing radiation03 medical and health sciences0302 clinical medicineBreast cancerbreast cancerCell Line TumormedicinecytokineHumansskin and connective tissue diseasesCell survivalRadiological and Ultrasound TechnologyChemistrybreast cancer cytokines inflammation Ionizing radiation Breast Neoplasms Cell Line Tumor Cell Survival Culture Media Conditioned Dose-Response Relationship Radiation Humans Phenotype Radiation ToleranceDose-Response Relationship Radiationmedicine.diseasecytokinesDose–response relationship030104 developmental biologyPhenotypeCell cultureinflammation030220 oncology & carcinogenesisCulture Media ConditionedImmunologyCancer researchmedicine.symptomBreast NeoplasmHuman
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Field- and irradiation-induced phenomena in memristive nanomaterials

2016

The breakthrough in electronics and information technology is anticipated by the development of emerging memory and logic devices, artificial neural networks and brain-inspired systems on the basis of memristive nano-materials represented, in a particular case, by a simple 'metal-insulator-metal' (MIM) thin-film structure. The present article is focused on the comparative analysis of MIM devices based on oxides with dominating ionic (ZrOx, HfOx) and covalent (SiOx, GeOx) bonding of various composition and geometry deposited by magnetron sputtering. The studied memristive devices demonstrate reproducible change in their resistance (resistive switching - RS) originated from the formation and …

Resistive touchscreenSettore FIS/02 - Fisica Teorica Modelli E Metodi MatematiciOxideIonic bondingNanotechnology02 engineering and technologyMemristorSputter deposition021001 nanoscience & nanotechnologyCondensed Matter Physics01 natural sciences010305 fluids & plasmasNanomaterialslaw.inventionIonchemistry.chemical_compoundchemistrylaw0103 physical sciences0210 nano-technologyMemristor resistive switching metal-oxide-metal nanostructure kinetic Monte-Carlo simulation radiation tolerance synaptic behaviour nonlinear dynamics stochastic resonanceElectrical conductor
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Proton-irradiated breast cells: molecular points of view

2019

Abstract Breast cancer (BC) is the most common cancer in women, highly heterogeneous at both the clinical and molecular level. Radiation therapy (RT) represents an efficient modality to treat localized tumor in BC care, although the choice of a unique treatment plan for all BC patients, including RT, may not be the best option. Technological advances in RT are evolving with the use of charged particle beams (i.e. protons) which, due to a more localized delivery of the radiation dose, reduce the dose administered to the heart compared with conventional RT. However, few data regarding proton-induced molecular changes are currently available. The aim of this study was to investigate and descri…

breast cancer cDNA microarray gene signature proton therapy radiation Breast Breast Neoplasms Cell Line Tumor DNA Complementary Dose-Response Relationship Radiation Female Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Inflammation MCF-7 Cells Oligonucleotide Array Sequence Analysis Phenotype Proton Therapy Radiation Tolerance Radiotherapy ProtonsDNA ComplementaryHealth Toxicology and Mutagenesismedicine.medical_treatmentBreast NeoplasmsCell fate determinationRadiation Tolerancegene signature03 medical and health sciences0302 clinical medicineBreast cancerbreast cancerCell Line TumorRegular Papermedicineproton therapyHumansRadiology Nuclear Medicine and imagingBreastClonogenic assayBiologyProton therapyOligonucleotide Array Sequence Analysis030304 developmental biologyInflammationcDNA microarray0303 health sciencesRadiotherapyChemistryGene Expression ProfilingBreast cancer; radiation; cDNA microarray; gene signature; proton therapyCancerDose-Response Relationship RadiationGene signaturemedicine.diseaseGene Expression Regulation NeoplasticGene expression profilingRadiation therapyradiationPhenotype030220 oncology & carcinogenesisMCF-7 CellsCancer researchFemaleProtons
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